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Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework

Received: 7 December 2020     Accepted: 15 December 2020     Published: 13 July 2021
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Abstract

Environment is witnessing an extensive increase in persistent and bioactive micro pollutants from the last few decades. Since most clinical modalities are flooded with antibiotics, environmental samples such as sewage treatment effluents, surface water and secondary water drainage etc. reveal the presence of bio-recalcitrant antibiotics worldwide, ergo there is a spurring rise in antibiotic resistant microorganisms. In order to circumvent the escalating concentration of amoxicillin (microgram/liter) we contrived a potential metal organic framework (MOF) and lab tested it for catalytic functionality. A zinc-porphyrin MOF using Tetra (4-carboxyphenyl) porphyrin H2TCPP (>97%) as a ligand and Zinc acetate as a metal salt was solvo-thermally synthesized. The morphological and structural characterization were performed using FESEM, XRD, EDAX, FTIR and UV-Visible spectroscopy. The fabricated MOF catalyst exhibits sterling ability of amoxicillin degradation in a dark environment at room temperature, accounting a degradation efficiency of about 97.3% in a 0.1 mg/ml concentration. 90 minutes of catalyst exposure to the antibiotic shows maximum degradation after which there is no further change in amoxicillin concentration. First time we have exploited electrochemical cyclic voltametric (CV) measurement to monitor the degradation process which was validated by FTIR recording, and noticed that the degradation process followed a first order kinetics. We have also discussed the morphological stability of the fabricated Zn porphyrin MOF after antibiotic exposure and reported a comparative outline between catalytic efficiency of different MOF species. High porosity and effective charge transfer between carboxyphenyl) porphyrin ligand to vacant d orbital of Zn+2 are pivotal factors for effective sorption and degradation of amoxicillin antibiotics dark at room temperature. We would expect the developed Zn porphyrin MOF is very promising for successful commercial application due to its energy efficiency (dark) and simple process for effective degradation of antibiotics.

Published in Advances in Materials (Volume 10, Issue 2)
DOI 10.11648/j.am.20211002.12
Page(s) 23-30
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Zn Porphyrin MOF, Amoxycillin, Room Temperature Degradation, FTIR Sensing

References
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    Shatakshi Saxena, Punya Saluja, JBM Krishna, Tinku Basu. (2021). Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework. Advances in Materials, 10(2), 23-30. https://doi.org/10.11648/j.am.20211002.12

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    ACS Style

    Shatakshi Saxena; Punya Saluja; JBM Krishna; Tinku Basu. Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework. Adv. Mater. 2021, 10(2), 23-30. doi: 10.11648/j.am.20211002.12

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    AMA Style

    Shatakshi Saxena, Punya Saluja, JBM Krishna, Tinku Basu. Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework. Adv Mater. 2021;10(2):23-30. doi: 10.11648/j.am.20211002.12

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  • @article{10.11648/j.am.20211002.12,
      author = {Shatakshi Saxena and Punya Saluja and JBM Krishna and Tinku Basu},
      title = {Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework},
      journal = {Advances in Materials},
      volume = {10},
      number = {2},
      pages = {23-30},
      doi = {10.11648/j.am.20211002.12},
      url = {https://doi.org/10.11648/j.am.20211002.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.am.20211002.12},
      abstract = {Environment is witnessing an extensive increase in persistent and bioactive micro pollutants from the last few decades. Since most clinical modalities are flooded with antibiotics, environmental samples such as sewage treatment effluents, surface water and secondary water drainage etc. reveal the presence of bio-recalcitrant antibiotics worldwide, ergo there is a spurring rise in antibiotic resistant microorganisms. In order to circumvent the escalating concentration of amoxicillin (microgram/liter) we contrived a potential metal organic framework (MOF) and lab tested it for catalytic functionality. A zinc-porphyrin MOF using Tetra (4-carboxyphenyl) porphyrin H2TCPP (>97%) as a ligand and Zinc acetate as a metal salt was solvo-thermally synthesized. The morphological and structural characterization were performed using FESEM, XRD, EDAX, FTIR and UV-Visible spectroscopy. The fabricated MOF catalyst exhibits sterling ability of amoxicillin degradation in a dark environment at room temperature, accounting a degradation efficiency of about 97.3% in a 0.1 mg/ml concentration. 90 minutes of catalyst exposure to the antibiotic shows maximum degradation after which there is no further change in amoxicillin concentration. First time we have exploited electrochemical cyclic voltametric (CV) measurement to monitor the degradation process which was validated by FTIR recording, and noticed that the degradation process followed a first order kinetics. We have also discussed the morphological stability of the fabricated Zn porphyrin MOF after antibiotic exposure and reported a comparative outline between catalytic efficiency of different MOF species. High porosity and effective charge transfer between carboxyphenyl) porphyrin ligand to vacant d orbital of Zn+2 are pivotal factors for effective sorption and degradation of amoxicillin antibiotics dark at room temperature. We would expect the developed Zn porphyrin MOF is very promising for successful commercial application due to its energy efficiency (dark) and simple process for effective degradation of antibiotics.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Morphological and Structural Elucidation of Room Temperature Catalytic Degradation of Amoxicillin Antibiotic Using Zinc Porphyrin Metal Organic Framework
    AU  - Shatakshi Saxena
    AU  - Punya Saluja
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    DO  - 10.11648/j.am.20211002.12
    T2  - Advances in Materials
    JF  - Advances in Materials
    JO  - Advances in Materials
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    EP  - 30
    PB  - Science Publishing Group
    SN  - 2327-252X
    UR  - https://doi.org/10.11648/j.am.20211002.12
    AB  - Environment is witnessing an extensive increase in persistent and bioactive micro pollutants from the last few decades. Since most clinical modalities are flooded with antibiotics, environmental samples such as sewage treatment effluents, surface water and secondary water drainage etc. reveal the presence of bio-recalcitrant antibiotics worldwide, ergo there is a spurring rise in antibiotic resistant microorganisms. In order to circumvent the escalating concentration of amoxicillin (microgram/liter) we contrived a potential metal organic framework (MOF) and lab tested it for catalytic functionality. A zinc-porphyrin MOF using Tetra (4-carboxyphenyl) porphyrin H2TCPP (>97%) as a ligand and Zinc acetate as a metal salt was solvo-thermally synthesized. The morphological and structural characterization were performed using FESEM, XRD, EDAX, FTIR and UV-Visible spectroscopy. The fabricated MOF catalyst exhibits sterling ability of amoxicillin degradation in a dark environment at room temperature, accounting a degradation efficiency of about 97.3% in a 0.1 mg/ml concentration. 90 minutes of catalyst exposure to the antibiotic shows maximum degradation after which there is no further change in amoxicillin concentration. First time we have exploited electrochemical cyclic voltametric (CV) measurement to monitor the degradation process which was validated by FTIR recording, and noticed that the degradation process followed a first order kinetics. We have also discussed the morphological stability of the fabricated Zn porphyrin MOF after antibiotic exposure and reported a comparative outline between catalytic efficiency of different MOF species. High porosity and effective charge transfer between carboxyphenyl) porphyrin ligand to vacant d orbital of Zn+2 are pivotal factors for effective sorption and degradation of amoxicillin antibiotics dark at room temperature. We would expect the developed Zn porphyrin MOF is very promising for successful commercial application due to its energy efficiency (dark) and simple process for effective degradation of antibiotics.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Centre for Converging Technologies, University of Rajasthan, Jaipur, India

  • Centre for Converging Technologies, University of Rajasthan, Jaipur, India

  • University Grants Commission, Department of Atomic Energy, Consortium For Scientific Research, Bidhan Nagar, Kolkata, India

  • Amity Centre for Nanomedicine, Amity University, Uttar Pradesh, India

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